Metamizole Sodium Injection is an analgesic drug for parenteral use
Metamizole (Dipyrone) Injection / Dimalgin®
What is Metamizole (Dipyrone)?
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Analgesic, Anti-inflammatory |
Therapeutic Class |
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Dog, Cow, Horse, Goat, Sheep, Pig |
Target Species |
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500mg Metamizole Sodium |
Active Ingredients |
Metamizole (Dipyrone)
Injection is an analgesic drug used to relieve severe pain and reduce fever in dogs, horses, and livestock like cows, goats, sheep, and pigs. It is an effective treatment for a high fever caused by infections, such as Eperythrozoon, toxoplasmosis, circovirus, and infectious pleurisy.
Due to its antispasmodic properties, it can also be used to treat gastrointestinal, biliary, or urinary colic, such as spasmodic pain in the reproductive system. The effectiveness of the drug in these scenarios is attributed to its ability to relax smooth muscles and alleviate the associated pain, thus providing comfort.
Metamizole sodium belongs to the family of medicines called ampyrone sulfonates. It displays strong antipyretic, spasmolytic, and analgesic properties and weak anti-inflammatory action. Metamizole is thought to work by inhibiting central cyclooxygenase-3 and activating the cannabinoid and opioidergic system.
After administration, metamizole is rapidly absorbed and metabolized into various compounds, with its primary active metabolite being 4-methylaminoantipyrine (MAA). This metabolite is known for its potent pain-relieving and fever-reducing properties. The metabolites are predominantly excreted through the kidneys, making renal function an important consideration in its use. The relatively quick onset of action and the duration of the effect make metamizole a practical choice in acute pain and fever management in veterinary settings.
Indications :
Analgesic – Antispasmodic – Anti-inflammatory – Antipyretic
Dosage and Administration :
Administered via intravenous (IV) or deep intramuscular (IM) injection
precautions :
Do NOT use Metamizole (Dipyrone) Injection for an animal that:
Treatment with this drug should be administered with caution if an animal:
If any adverse effects are observed, discontinue the medication immediately and seek veterinary assistance. Supportive care, depending on the nature of the side effect, may involve symptomatic treatment such as antihistamines for allergic reactions or fluid therapy for gastrointestinal issues.
Regular blood tests may also be advised to monitor the animal's health status, especially in cases of prolonged use. Maintain a detailed record of any medications administered concurrently, as interactions with other drugs may exacerbate side effects.
Side Effects :
As with all pharmaceuticals, some unwanted effects can occur from the use of Metamizole Injection.
Adverse effects are not common, but there are rare reports of serious side effects such as :
Metamizole (Dipyrone) has specific applications and effects in different animals like:
It's used to reduce fever and treat moderate to severe pain such as:
This drug is recommended for dogs, horses, and livestock like cows, horses, sheep, goats and pigs.
Metamizole inhibits central cyclooxygenase enzymes, reducing the production of pain-inducing prostaglandins. Its antispasmodic properties help in relieving muscle spasms, particularly useful in treating colic pain in animals. Metamizole's activation of the cannabinoid and opioidergic systems also enhances its analgesic effects.
This medication has been manufactured as a liquid, which is packaged in a vial. It is intended to be administered by IM/IV injection. Metamizole (Dipyrone) Injection is intended for veterinary use only.
It may be given every 8-12 hours, but the exact regimen should be determined by a veterinarian. The frequency of administration depends on the condition being treated and the animal's response to therapy.
The withdrawal time is 5 days. This is the time required after the last administration of the medication before the animal can be safely slaughtered for food production, ensuring that no harmful residues remain in the meat. Milk from dairy animals treated with the drug should not be used for human consumption during the treatment and for a similar duration after the last dose.
Metamizole typically begins to take effect within 30 minutes to an hour after administration, but this can vary depending on the animal and the condition being treated.
Yes, the dosage might be adjusted within the recommended range (20-50mg/kg) based on the severity of the symptoms and the animal's overall health status. However, such adjustments should always be made under veterinary supervision.
It is generally reserved for moderate to severe pain and high fever due to its potent effects. For mild conditions, other medications may be more appropriate.
Yes, it can interact with several other drugs. Its use alongside other non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulants can increase the risk of adverse effects. It may also interfere with the efficacy of certain blood pressure medications and cyclosporine, a drug commonly used in immunosuppressive therapy.
Yes. Its efficacy in providing relief from moderate to severe pain, especially visceral pain, post-surgical pain, and pain associated with colic, attests to its potency as an analgesic. It is often a drug of choice in veterinary medicine for treating acute and intense pain in various animals.
This medication should be stored in a dark, dry location under 30°C. The vial should be sealed tightly. Always check the expiration date before use.
The usual dose is 20-50mg/kg, given at slow rate IV/IM. For horses only, use slow intravenous administration.
The typical dosage for dogs ranges from 20-50mg/kg. It can be administered either IV or IM, depending on the severity of the condition and the veterinarian's discretion.
Sheep and goats usually receive this drug at a dose of 20-50mg/kg. The route of administration can be either IV or IM, based on the clinical situation and the judgment of the veterinary professional.
For pigs, the recommended dosage is similar, at 20-50mg/kg, also through either IV or IM routes.
If an overdose is suspected, immediate veterinary attention is critical. Overdose can lead to symptoms like hypotension, gastrointestinal disturbances, or neurological signs. Treatment is generally supportive and symptomatic.
In geriatric or debilitated animals, it is important to start with the lower end of the dosage range (20mg/kg) and closely monitor for any adverse effects. Adjustments may be made based on the animal's response and tolerance to the drug.
Refer to a veterinary doctor or pharmacist for guidelines on dosage.
