Niclosamide Boluses/ Niclodima^®

What is Niclosamide ?

Niclosamide

is a cestocidal (tapeworm-killing) drug. Its anthelmintic activity is achieved by inhibiting glucose absorption and uncoupling oxidative phosphorylation in the mitochondria of cestodes. This disruption of the Krebs cycle leads to the accumulation of lactic acid, ultimately resulting in the death of tapeworms.

Indications :

Niclodima is an anthelmintic preparation recommended for the treatment of infections caused by various tapeworms, including Dipylidium caninum, Taenia pisiformis, Taenia hydatigena, Taenia taeniaeformis (also known as thick-necked tapeworm), Mesocestoides corti, Mesocestoides lineatus, and Echinococcus granulosus in dogs and cats.

It is also effective against ciliated tapeworms (Thysanosoma spp.), Moniezia spp., and immature paramphistomes in cattle, sheep, and goats.

Dosage and Administration :

• Cattle, sheep, and goats: 75 mg per kg of body weight, administered as a single oral dose, either directly or using a bolus gun.
  (Equivalent to 1 bolus per 50 kg of body weight.)
• Dogs and cats: 15 mg per kg of body weight, administered as a single dose.
  (Equivalent to 0.25–1 bolus depending on body weight.)

Side Effects :

No side effects have been reported.
The product can be safely administered to pregnant or debilitated animals.