Dimapen

^{Procaine Penicillin and Dihydrostreptomycin}

^DIMAPEN® 

What is DIMAPEN?

Therapeutic Class:
• Antibiotic Combination (β-lactam + Aminoglycoside)

Target Species:
• Cattle
• Horses
• Sheep
• Pigs

Active Ingredients:
• Procaine Penicillin: 200 mg
• Dihydrostreptomycin Sulphate: 250 mg

DIMAPEN Suspension for Injection is a broad-spectrum veterinary antibiotic combining procaine penicillin and dihydrostreptomycin, providing effective treatment against a wide range of gram-positive and gram-negative bacteria. It is used to manage acute and systemic infections, as well as to control secondary bacterial complications following viral illnesses.

This injectable suspension offers a synergistic effect:

• Penicillin G: bactericidal action via inhibition of bacterial cell-wall synthesis.
• Dihydrostreptomycin: an aminoglycoside that inhibits protein synthesis at the 30S ribosomal subunit.

Together they deliver rapid, reliable action in food-producing animals and horses

Indications:

procaine penicillin and dihydrostreptomycin are indicated for the treatment of systemic infections caused by organisms sensitive to penicillin and/or streptomycin, including:

• Arcanobacterium pyogenes
• Erysipelothrix rhusiopathiae
• Klebsiella pneumoniae
• Listeria spp
• Mannheimia haemolytica
• Pasteurella multocida
• Staphylococcus spp (non-penicillinase producing)
• Streptococcus spp
• Salmonella spp

It is also used to control secondary bacterial infections complicating viral diseases.

Suspension for Injection is a broad-spectrum antibiotic combination used to treat systemic and localised bacterial infections in several animal species, including cattle, horses, sheep, and pigs.

It is effective against infections caused by bacteria sensitive to penicillin and/or streptomycin, such as:

• Arcanobacterium pyogenes
• Erysipelothrix rhusiopathiae
• Klebsiella pneumoniae
• Listeria species
• Mannheimia haemolytica
• Pasteurella multocida
• Staphylococcus spp. (non-penicillinase producing)
• Streptococcus spp.
• Salmonella spp.

Dosage and Administration             

• Shake well before use to ensure uniform suspension. Deep intramuscular injection only.

Dose:
• 1 mL per 25 kg bodyweight
(Equivalent to approximately 8 mg/kg procaine penicillin + 10 mg/kg dihydrostreptomycin.)

Treatment duration:
• Administer once daily for up to 3 consecutive days, or as directed by the veterinarian based on clinical response.

Precautions

Do NOT use DIMAPEN in animals that:
• Have known hypersensitivity to penicillins or aminoglycosides
• Have renal impairment (use with caution)

People administering the product should avoid:
• Accidental self-injection
• Contact if previously sensitized to β-lactams

Seek medical attention if allergic symptoms occur.

Do NOT combine with:
• Tetracyclines
• Other aminoglycosides

Side Effects

DIMAPEN is generally well tolerated; however, some animals may exhibit mild to rare adverse reactions:

1. Hypersensitivity Reactions (Allergic Reactions)

• May occur in animals sensitive to penicillins or aminoglycosides.
• Signs include:

• Swelling at the injection site
• Urticaria (hives)
• Respiratory difficulty
• Collapse (very rare, severe anaphylaxis)
  • Immediate veterinary intervention is required in severe cases.

• Mild, transient swelling may occur—especially in horses.
• Typically resolves within a short period without treatment.

3. Systemic Reactions in Pigs (Rare)

Pigs may occasionally show:
• Fever
• Vomiting
• Shivering
• Incoordination
These effects are usually short-lived and resolve spontaneously.

4. Gastrointestinal + Renal Considerations

Because dihydrostreptomycin is an aminoglycoside:
• Use caution in animals with compromised kidney function, as accumulation may increase toxicity risk.
• Toxic effects are rare when dosage guidelines are followed.

5. Effects During Pregnancy (Pigs)

• Pregnant sows and gilts may rarely exhibit vulval discharge that could be associated with abortion.
• Use only under veterinary supervision during pregnancy.